Stab Injury with Tailoring Scissor Causing Inferior Gluteal Artery Pseudo Aneurysm: a Rare Case Report

Background: Gluteal artery pseudo aneurysm (GAP) is a rare entity, as gluteal arteries are well protected under muscles and fat of gluteal region. Gluteal artery aneurysms constitute less than 1% of all aneurysms and most of them are pseudo aneurysms.  The common etiologies of GAP  areblunt or penetrating trauma to gluteal region, infection, fractures of the pelvis or iatrogenic injury during surgical procedures on the pelvis or hips to intramuscular injection. The usual presentation is a pulsatile gluteal mass often confused with a gluteal abscess presenting 1-2 months after injury. However, at times it can cause symptoms due to compression of pelvic structures.Case Report: Our patient was a young boy who had injury to his right gluteal region with a tailoring scissor during a scuffle. He presented to casualty in shock with packing of wound done outside. After resuscitation his Computed tomographic angiography (CT angiography) revealed a psuedoanuerysm of inferior gluteal artery. He was immediately taken up for surgery a transperitoneal ligation of internal iliac artery of the involved side was done along with exploration of the gluteal wound.Conclusion: These patients of Gluteal artery aneurysms can be managed with both open and endovascular techniques. Our patient was unique in the respect that no GAP has been reported after stab injury with a tailoring scissor and ours is first case report in English literature .We want that the surgeons should keep in mind the possibility of GAP while dealing with even trivial injuries of gluteal region

Integration of waqf-Islamic microfinance model for poverty reduction: the case of Bangladesh

Purpose – This paper aims to develop an integrated waqf-based Islamic microfinance (IsMF) for poverty reduction in Bangladesh. Microfinance institutions (MFIs) have been constrained by the high cost of funds, high interest rate charges and poor human resource quality of the recipients. Islamic MFIs have recently evolved with the hope of overcoming these financial, ethical and human capital deficiencies faced by the conventional financial institutions. Moreover, a good number of integrated models have been proposed to enhance the role played by Islamic MFIs. Most of these models, however, lack empirical justifications. Design/methodology/approach – The research uses survey techniques. A total of 381 respondents were included in the survey. The integrated waqf-based Islamic microfinance model (IWIMM) was earlier on developed using literature and intellectual discussions. There are six constructs presenting the IWIMM, namely, waqf resources, IsMF, takaful, project financing, human resource development and poverty alleviation. In the survey instrument, 45 items represent the six constructs, but only 26 items have been retained after factor analysis. Structural equation modelling has been adopted to examine the relationship among the constructs. Findings – The results show that there are significant relationships between IsMF and takaful, waqf resources and human resource development, takaful and human resource development, IsMF and human resource development and, waqf resources and project financing. The results also indicate that poverty alleviation is possible through the integration of these constructs. Research limitations/implications – Though the paper has studied conventional and Islamic MFIs in Bangladesh, one of the populated Organisation of Islamic Cooperation (OIC) member countries and also where poverty incidence is high, further studies need to be conducted in other OIC member countries to adopt the model in line with practical and regulatory environment of those countries. Similarly, the study is based on the perception of the respondents, which limits the generalization of the result. Practical implications – The paper proposed a model that has the potential of being applied for poverty alleviation programmes in most of the OIC member states. Originality/value – The present paper has developed an IWIMM for poverty reduction

Molecular Docking of Known Carcinogen 4- (Methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) with Cyclin Dependent Kinases towards Its Potential Role in Cell Cycle Perturbation

Cell cycle is maintained almost all the times and is controlled by various regulatory proteins and their complexes (Cdk+Cyclin) in different phases of interphase (G1, S and G2) and mitosis of cell cycle. A number of mechanisms have been proposed for the initiation and progression of carcinogenesis by abruption in cell cycle process. One of the important features of cancer/carcinogenesis is functional loss of these cell cycle regulatory proteins particularly in CDKs and cyclins. We hypothesize that there is a direct involvement of these cell cycle regulatory proteins not only at the genetic level but also proteins level, during the initiation of carcinogenesis. Therefore, it becomes significant to determine inconsistency in the functioning of regulatory proteins due to interaction with carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Hence, we investigated the interaction efficiency of NNK, against cell cycle regulatory proteins. We found a different value of ΔG (free energy of binding) among the studied proteins ranging between -3.29 to -7.25 kcal/mol was observed. To validate the results, we considered Human Oxy-Hemoglobin at 1.25 Å Resolution, [PDB_ID:1HHO] as a +ve control, (binding energy -6.06 kcal/mol). Finally, the CDK8 (PDB_ID:3RGF) and CDK2 (PDB_ID:3DDP) regulatory proteins showing significantly strong molecular interaction with NNK -7.25 kcal/mol, -6.19 kcal/mol respectively were analyzed in details. In this study we predicted that CDK8 protein fails to form functional complex with its complementary partner cyclin C in presence of NNK. Consequently, inconsistency of functioning in regulatory proteins might lead to the abruption in cell cycle progression; contribute to the loss of cell cycle control and subsequently increasing the possibility of carcinogenesis

Iqbal’s Antagonism towards Pseudo-Mysticism

Ever since time immemorial, there has been a constant search in people of all religious traditions to unravel the mystery on how man arrived on this planet and what should be his ideal relationship with God and other life forms. Though all religions have their rituals and doctrine to explain on the God-Man relationship, for some the hunger and thirst to understand God at a much deeper level take them to the path of mysticism. For such people, religion is the outward journey of man towards God, while mysticism is the inward journey of the human soul towards the Absolute. Although mysticism is good as a soul elevating experience, nevertheless at times it can take people away from the reality of life into the other worldliness causing problem to their earthly existence; obligation towards family, society, nation and humanity. The present study is geared towards understanding Iqbal’s views on mysticism. As a mystic-poet and philosopher, at one point of time in his life, Iqbal took great interest in Islamic Mysticism (Tasawwuf); particularly ideas presented by Ibn Arabi (1165-1240) a 12th century Sufi scholar. Later, after his travel and studies in Europe and his eventual involvement in politics, Iqbal took an antagonistic stand against some aspects of Sufism. Through this study, the research team would like to investigate as to why he disagreed and criticized some aspects of Sufism. Relevant data to the study will be collected from print and internet sources. As a qualitative study, the content and textual-analysis methods will be used to analyze the pertinent data

Effect of laser micro-drilling parameters on hole geometry and hole formation of thin sheet SS304

The recent advances in manufacturing technology have led to the development of miniature products in the field of automobiles, aerospace, and robotics. Laser micro-drilling has developed as a potential substitute over conventional machining due to the advantages of operational precision, reduced operational costs, and a high-speed production rate. This process involves high power intensity from the laser to break down the bond between molecules of the workpiece and hence form a hole on the workpiece. This project aims to study the effect of laser power on the drilled hole geometry and to analyse the mechanism of the hole formation during laser micro-drilling. The material used in this project is SS304 sheet metal. The holes’ geometry and hole formation will be analysed by using an optical microscope. The size of the hole diameter for each power is almost the same in the range of 101.669–102.978 μm for the frontside. Meanwhile, the diameter of the backside hole increases from 64.343 μm to 88.852 μm at 15 W to 21 W of laser power respectively. For hole formation, the more material is ablated as the ablation process advances. As a result, the removal area from the micro-drilled hole grows from 3577.852 to 6516.237 m2. The shape of the hole is irregular due to the uneven power distribution of the laser towards the SS304 sheet metal when it undergoes an ablation process

Performance analysis of frequency shift estimation techniques in Brillouin distributed fiber sensors

The performance of post-processing techniques carried out on the Brillouin gain spectrum to estimate the Brillouin frequency shift (BFS) in standard Brillouin distributed sensors is evaluated. Curve fitting methods with standard functions such as polynomial and Lorentzian, as well as correlation techniques such as Lorentzian Cross-correlation and Cross Reference Plot Analysis (CRPA), are considered for the analysis. The fitting procedures and key parameters for each technique are optimized, and the performance in terms of BFS uncertainty, BFS offset error and processing time is compared by numerical simulations and through controlled experiments. Such a quantitative comparison is performed in varying conditions including signal-to-noise ratio (SNR), frequency measurement step, and BGS truncation. It is demonstrated that the Lorentzian cross-correlation technique results in the largest BFS offset error due to truncation, while exhibiting the smallest BFS uncertainty and the shortest processing time. A novel approach is proposed to compensate such a BFS offset error, which enables the Lorentzian cross-correlation technique to completely outperform other fitting methods

Microstructure analysis and mechanical properties of dissimilar AA6061-AA7075 laser brazing with prefixed ER5356 filler

Laser brazing uses a filler metal for joining without melting the base material. This process is a versatile joining technique for a wide range of applications including automotive, aerospace, and medical field because of the ability in joining dissimilar metal and resulted good quality in surface's joint. This study consists of aluminium alloy of AA6061 and AA7075 as a base material with aluminium based ER5356 as a wire filler. Laser brazing was performed using 1.2 kW of laser power, while wire filler was let to be prefixed without using the wire feeder because of using the existing laser welding machine. Microstructure of the joints were studied using 3D measuring laser microscope OLS5000. Besides that, mechanical properties of the joints were evaluated by performing tensile test and hardness test. Microstructures of the brazed joints show the differences in the grain structure followed by the difference's hardness value on each region. The brazed joint shows the average ultimate tensile strength reached 154.71 MPa which was 50% of joint efficiency. However, there is porosities at the fracture surface of the joint

Effect of filler composition on microstructure and mechanical properties of MIG welded AA6061 and AA7075

Nowadays, aluminium alloy is hugely applied in the automotive and aircraft sector due to its lightweight and considerable hardness. For joining aluminium alloys, fusion welding methods are widely used due to its low cost. Apart from that, Metal Inert Gas (MIG) was generally applied by welders. Be that as it may, different filler compositions utilised in MIG welding dissimilar aluminum alloy can create a different microstructure, and defect happens during welding and influencing joint microstructure, and mechanical properties. The aim of this study is to identify the weldability, study the mechanical properties and investigate the effect of alloy element on microstructure of joining aluminium alloy AA6061 and AA7075. In order to achieve comparable welded quality and appearance, the welding parameters used for all setup must be the same. Four different types of filler metal were used, which were ER4043, ER4047, ER5183 and ER5356. For Vickers hardness and tensile test, a few samples from the welded specimens will be cut by using EDM wire cut machine, following the ASTM-E8 standard. The microstructure will be analysed using the same sample used for the hardness test. Meanwhile, for tensile test result, the ultimate tensile strength (UTS) of filler ER4047 with 13% silicon is the highest, 170.2 MPa, followed by filler ER5356 with 5% magnesium, 161.8 MPa, slightly decreased by filler ER4043 with 6% silicon and ER5183 with 4% magnesium are 159.78 and 159.6 MPa. All samples are fracture at AA6061 side for the hardness test. Base metal (BM) AA6061 gives a lower value than the heat affected zone (HAZ) and fusion (FZ) of both materials. The variations in the grain structure are seen by the microstructures of welded joints. By visual inspection, the defects presented in the welded joint were detected from its macrostructure

Effectiveness of Antibiotic Prophylaxis for Leptospirosis among Adults: A Systematic Review

Leptospirosis is one of the most widespread re-emerging zoonoses in the world. Malaysia is known to be an endemic country for human leptospirosis, with a case fatality rate of 2.11%, and an average annual incidence rate of 7.80 cases per 100,000 individuals. This systematic review is conducted to determine the effectiveness of antibiotic prophylaxis for leptospirosis among the adult populations who are highly at risk of getting infected. A systematic search was performed for the relevant titles, abstracts and keywords on PubMed, Scopus, Cochrane and Google Scholar from inception to November 2017 based on the PICO strategy; which returned 126 studies. Screening of abstracts had shortlisted 19 studies and data extraction was conducted for 8 studies which had been accepted after review of the full text. For the evaluation of antibiotics prophylaxis effectiveness against leptospirosis, only trials and cohort studies with risk ratio (RR) were selected. The articles were analyzed from the viewpoint of the dosage, adverse effects, study settings and effectiveness of the antibiotic prophylaxis. Using fixed effects model, pooled RR showed protective association between antibiotic prophylaxis use against the incidence of leptospirosis (RR = 0.31; 95% CI: 0.20, 0.48). Antibiotic prophylaxis for leptospirosis had been shown to be effective in preventing the incidence of the disease among high-risk populations and carries minimal adverse effects. It is recommended that the practice of antibiotic prophylaxis for leptospirosis is included in the standard protocol for leptospirosis prevention among people at high-risk, including disaster response teams and patrons of eco-sports tourism activities; with the drug of choice being doxycycline, either as a single 200 mg dose or weekly dose of 200 mg for the duration of exposure, based on the setting, duration of event and resources available